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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM2
All Species:
40
Human Site:
S139
Identified Species:
58.67
UniProt:
P49736
Number Species:
15
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49736
NP_004517.2
904
101896
S139
R
R
G
L
L
Y
D
S
D
E
E
D
E
E
R
Chimpanzee
Pan troglodytes
XP_001136482
895
100908
S130
R
R
G
L
L
Y
D
S
D
E
E
D
E
E
R
Rhesus Macaque
Macaca mulatta
XP_001099580
870
97929
S139
R
R
G
L
L
Y
D
S
D
E
E
D
E
E
R
Dog
Lupus familis
XP_541736
1001
113024
S237
R
R
G
L
L
Y
D
S
D
E
E
D
E
E
R
Cat
Felis silvestris
Mouse
Mus musculus
P97310
904
102059
S139
R
R
G
L
L
Y
D
S
S
E
E
D
E
E
R
Rat
Rattus norvegicus
NP_001101343
905
102125
S140
R
R
G
L
L
Y
D
S
D
E
E
D
E
E
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518428
911
102482
S147
R
R
G
L
L
Y
D
S
D
E
E
E
E
G
R
Chicken
Gallus gallus
NP_001006139
888
100332
S125
R
R
G
L
L
Y
D
S
D
D
E
D
E
D
R
Frog
Xenopus laevis
P55861
886
100243
S123
R
R
G
L
L
Y
D
S
D
E
E
E
E
D
R
Zebra Danio
Brachydanio rerio
NP_775364
880
98286
S123
G
R
G
L
L
Y
D
S
E
D
E
D
D
K
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49735
887
100396
Q123
D
R
D
L
G
F
G
Q
S
D
D
E
D
D
V
Honey Bee
Apis mellifera
XP_395109
1005
114136
E244
D
R
Y
L
L
Y
D
E
S
D
E
E
E
M
Q
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
E82
N
H
L
K
N
F
D
E
D
I
E
M
K
L
R
Sea Urchin
Strong. purpuratus
XP_001177558
884
100012
E124
R
P
G
L
L
Y
E
E
S
D
E
E
D
E
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
G91
D
P
K
F
L
K
E
G
E
R
V
M
V
G
F
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P29469
868
98761
D130
L
R
N
V
A
Y
I
D
D
E
D
E
E
Q
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.8
87.4
N.A.
95.5
96
N.A.
93.1
88.2
86.7
80.1
N.A.
63.9
58.4
26.7
73.4
Protein Similarity:
100
99
96.1
89.1
N.A.
97.7
98.3
N.A.
95.7
93.8
93
87.6
N.A.
79.3
73.5
43.2
86.5
P-Site Identity:
100
100
100
100
N.A.
93.3
100
N.A.
86.6
86.6
86.6
66.6
N.A.
13.3
46.6
26.6
53.3
P-Site Similarity:
100
100
100
100
N.A.
93.3
100
N.A.
93.3
100
100
93.3
N.A.
53.3
66.6
40
80
Percent
Protein Identity:
N.A.
30.3
N.A.
N.A.
41.9
N.A.
Protein Similarity:
N.A.
48.8
N.A.
N.A.
58.9
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
N.A.
20
N.A.
N.A.
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
19
0
7
0
0
0
75
7
63
32
13
50
19
19
0
% D
% Glu:
0
0
0
0
0
0
13
19
13
57
82
38
69
44
7
% E
% Phe:
0
0
0
7
0
13
0
0
0
0
0
0
0
0
7
% F
% Gly:
7
0
69
0
7
0
7
7
0
0
0
0
0
13
0
% G
% His:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
7
0
0
7
0
0
0
0
0
% I
% Lys:
0
0
7
7
0
7
0
0
0
0
0
0
7
7
0
% K
% Leu:
7
0
7
82
82
0
0
0
0
0
0
0
0
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
13
0
7
0
% M
% Asn:
7
0
7
0
7
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
13
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
7
0
0
0
0
0
7
7
% Q
% Arg:
63
82
0
0
0
0
0
0
0
7
0
0
0
0
75
% R
% Ser:
0
0
0
0
0
0
0
63
25
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
7
0
0
0
0
0
0
7
0
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
82
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _